The history of the Central University of Venezuela starts with the foundation of the Colegio Santa Rosa de Lima by Antonio González de Acuña in 1673, which was inaugurated on August 29, 1696 by Diego Baths Sotomayor. Ironically, in the seminary chapel he was declared the Independence of Venezuela on July 5, 1811, and was at the same institution where many of the drafters and signatories of the minutes were formed. Currently this building serves as Palacio Municipal de Caracas
The December 22, 1721, after many efforts by Venezuelans, King Felipe V granted authority to grant degrees Seminar by Royal Decree and December 18, 1722 Pope Innocent XIII granted Pontifical character. Initially kinds of theology, medicine, philosophy and law were held, all in Latin, but eventually the academic system is independent of the seminar and the August 11, 1725, the Bishop of Caracas Juan Jose Escalona and Calatayud (who had managed the establishment of the institute), install the Real and Pontifical Seminary University Santa Rosa de Lima to Santiago de León Caracas Valley. His first director was the presbítero Francisco Martínez de Porras and until 1810, when the Seminary of San Buenaventura de Merida was elevated to University (now University of Los Andes), the de Caracas was the only one in the country.