The Wellcome Trust Sanger Institute is one of the premier centres of genomic discovery and understanding in the world. It leads ambitious collaborations across the globe to provide the foundations for further research and transformative healthcare innovations. Its success is founded on the expertise and knowledge of its people and the Institute seeks to share its discoveries and techniques with the next generation of genomics scientists and researchers worldwide. Fewer than 50 people were employed when the Sanger Institute, then called the Sanger Centre, was officially opened on 4 October 1993; today more than 1000 people work here and nearly 2000 people in total work on the Wellcome Genome Campus. With a vision to provide world-class research on a large scale, we have evolved from principally a sequencing centre to a leader in genomics research. Set on this path by John Sulston, founding Director, the Institute grew and matured under Allan Bradley (Director from 2000-2010). Allan's vision reshaped the Institute's scientific portfolio: he transformed the Sanger Institute from a world leading sequencing centre to encompass ground breaking research into the impact of genetics on health and disease. The Institute's current Director, Mike Stratton, leads the Institute as it enters a new era of genome research - an era that will be about application of genomics research to develop new diagnostics and precision treatments for patients.