The mission of the Center is to create a rich intellectual environment and a supportive academic environment, to address this grand challenge, with an emphasis on rethinking what is possible. We do this through international, interdisciplinary, multi-level analyses, ranging from genes to societies, that utilize multiple methods in human studies and animal models.  The common core for  CCSN is rigor, quantification, and theoretical sophistication shaped by reproducible empiricism designed to disconfirm, or at least to identify the limits of, rather than to confirm apriori expectations.